SOCS1 and colorectal carcinoma: In CA-CRC, the hypermethylation frequencies of NTSR1, SOCS2, and SOCS1 (32–42%) clearly exceeded those of the paired normal tissues (0%); however, statistical significances were lost when the Bonferroni correction was applied (Figure 4a), and only NTSR1 remained borderline significant (p = 0.057).