In our investigation, methylation levels of NTSR1 (Figure 5) and at least one of the probes for all CIMP marker genes except MLH1 (Supplementary Table S3) were significantly higher in CA-CRC-derived normal mucosae compared to LS-derived normal mucosae, suggesting the existence of hypermethylated fields in the normal mucosae from CA-CRC patients. This evidence concerns the gene NTSR1 and cancer.