Intriguingly, normal mucosa samples of CA-CRC vs. LS patients differed significantly: the average degree of methylation for NTSR1 was significantly higher in normal mucosa from CA-CRC patients (mean Dm ± SD of 0.29 ± 0.12, range 0.22–0.36) compared to normal mucosa from LS patients (0.21 ± 0.15, range 0.16–0.31) (p = 0.007). This evidence concerns the gene NTSR1 and cancer.