Aggressive histological features, i.e., mucinous and poorly differentiated tumors, also characterize Lynch syndrome (LS)-associated CRC [6], where the cumulative risk of CRC depends on the predisposing mutation: carriers of MLH1 or MSH2 germline mutations have over 10-fold relative risks compared to the general population [7]. This evidence concerns the gene MSH2 and colorectal carcinoma.