MGMT and colorectal cancer: Prompted by the observations of elevated methylation of NTSR1 and CIMP marker genes as a feature of normal mucosae from CA-CRC patients (Figure 5, Supplementary Table S3), the repair gene O-6-Methylguanine-DNA Methyltransferase (MGMT) was investigated for promoter methylation, as it has been proposed to serve as an early marker for colorectal cancer [30].