Pitavastatin mitigated experimental AAAs induced by either elastase infusion in normocholesterolemic rats, or Ang II infusion in hypercholesterolemic mice, in conjunction with enhanced intracellular drug concentrations resulting from nanoparticle-enhanced delivery, also without apparent effect on serum cholesterol concentrations [30,31]. The gene discussed is AGT; the disease is achalasia-alacrima syndrome.