NFE2L2 and obesity due to melanocortin 4 receptor deficiency: These include obesity (as a consequence of long-term HFD) in the absence of hypercholesterolemia, neutralization of transforming growth factor-β, chemical destabilization of extracellular matrix protein cross-linking via β-aminopropionitrile monofumarate administration, and genetic deficiency of nuclear factor erythroid 2-related factor 2 [35,38,39,40,41,42].