CBLN1 and Insulin resistance: A subsequent reduction in oxidative phosphorylation results in an accumulation of metabolic intermediates, i.e., diacylglycerols (DG) and ceramides (CER) [162] that may contribute to the development of insulin resistance via an inhibition of insulin receptor signaling mediated through an interaction with Proteinkinase C (PKC) in case of DG or with AKT in case of CER.