For example, increased NNMT expression in pancreatic cancer creates a “metabolic sink” whereby intracellular SAM levels are reduced due to NNMT overactivity, the consequence of which is the upregulation of the expression of several cancer-related genes such as SNAI2, ADAMTS6, TGFB2, LAMB3 and CNTN1 [137]. This evidence concerns the gene NNMT and familial pancreatic carcinoma.