Misfolding and aggregation of α-synuclein (α-Syn) play a crucial role in the progression of neurodegenerative diseases, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and multiple system atrophy (MSA), altogether termed as synucleinopathies [1]. Here, SNCA is linked to multiple system atrophy.