Misfolding and aggregation of α-synuclein (α-Syn) play a crucial role in the progression of neurodegenerative diseases, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and multiple system atrophy (MSA), altogether termed as synucleinopathies [1]. The gene discussed is SNCG; the disease is Lewy body dementia.