The potential mechanism linking PTX3 levels and insulin resistance could be the phosphatidylinositol 3-kinase (PI3K) and downstream signaling pathways, including protein kinase B. Recent studies have found PI3K/Akt activation-dependent expression of PTX3 in endothelial cells [47], suggesting a possible link between PTX3 and insulin signaling. This evidence concerns the gene AKT1 and Insulin resistance.