Fu et al. proved that JMJD2B can be combined with HIF-1α to reduce H3K9me3 on the promoter of HIF-1α targeted genes, such as LDHA, GLUT1/3, HK2, von Hippel-Lindau (VHL) and monocarboxylate transporters 4 (MCT4), to up-regulate their expression and contribute to the malignant phenotype of CRC [170]. This evidence concerns the gene HK2 and colorectal carcinoma.