In this context, Bebek et al. studied the relationship between three factors: (i) microbial profile, (ii) neck squamous cell carcinoma (HNSCC), and (iii) the methylation status of four genes (MDR1, IL8, RARB, and TGFBR2) linked to HNSCC and inflammation [47]. This evidence concerns the gene RARB and head and neck squamous cell carcinoma.