As 4-HNE and H2O2 impair TRPV1 function, they may further lead to a deficiency in nitric oxide production, a central characteristic of diabetes-induced endothelial dysfunction, as described earlier in this review, when illustrating 12(S)-HETE) and TRPV1 interaction [65,66,67]. Here, TRPV1 is linked to diabetes mellitus.