TRPV1 and diabetes mellitus: Another possible TRPV1 antagonist is 4-(3-chloro-2-pyridinyl)-N-[4-81,1-dimethylethyl)phenyl]-1-piperazine-carboxamide (BCTC), which has previously been used for the antagonization of TRPV1 in a study of diabetes and in another study on pain relief [60,134].