Furthermore, the administration of Alda-1 (N-(1,3-benzodioxol-5-ylmethyl)-2,6 di-chloro-benzamide), an activator of ALDH2, protects against ischemia reperfusion injury and ALDH2 upregulation, leading to aldehyde clearance that may thus prove beneficial in myocardial ischemia-reperfusion, coronary bypass surgery, or the reperfusion of an organ transplant [164]. The gene discussed is ALDH2; the disease is myocardial ischemia.