LGALS1 and melanoma: Cedeno-Laurent et al. showed that limiting Gal-1-binding to LacNAc on T cell membrane proteins with peracetylated 4-fluoro-glucosamine (4-F-GlcNAc) (Figure 2B), a metabolic inhibitor of LAcNAc biosynthesis, decreased the growth of B16 melanomas and EL-4 lymphomas.