That is, similar to the expression patterns of CACT and CPT2, CrAT protein levels also correlated negatively with an increase in tumor malignancy and had the lowest levels in the most malignant cell types (G3), again consistent with a previous report in which CrAT expression was significantly lower in human muscle-invasive bladder cancer compared with normal bladder tissue [33]. This evidence concerns the gene CRAT and neoplasm.