A recent study investigated whether the anti-obesity and anti-inflammatory properties of tea polyphenols are associated with the inhibition of COX2 and inducible nitric oxide synthase (NOS2) expression levels via the modulation of COX2 signaling pathways and a consequent inflammatory cytokine response in liver [47] and intestinal epithelial in dogs [70]. Here, PTGS2 is linked to obesity due to melanocortin 4 receptor deficiency.