Other evidence emerges from the study of Liu et al. (2017), who demonstrated that apigenin administration improved the cardiac functions and mitigated the cardiac hypertrophy and interstitial fibrosis in a mouse model of diabetic cardiomyopathy by attenuating myocardial oxidative stress (i.e., 4-hydroxynonenal and malondialdehyde) and improving the activity of SOD and GPX [107]. The gene discussed is SOD1; the disease is cardiac hypertrophy.