SOD1 and cardiac hypertrophy: In spontaneously hypertensive rats (SHRs), Gao et al. (2021) have found that bilateral hypothalamic paraventricular nucleus (PVN) chronic infusion of apigenin attenuated the increase of mean arterial pressure, cardiac hypertrophy and fibrosis, positively affecting PVN oxidative stress due to its ability to modulate the NADPH oxidase-dependent ROS generation and to restore the activity of superoxide dismutase 1 (Cu/Zn-SOD) and the 67-kDa isoform of glutamate decarboxylase (GAD67) [90].