Thus, considering that one of the main causes of the pathogenesis of osteoarthritis and its associated comorbidities is generated by oxidative stress, PI3K/p-AKT activation, and pro-inflammatory and pro-apoptotic responses [11,25,27], their inhibition with DADS and GYY4137 might possibly explicate their anxiolytic and antidepressant actions in this pain model. Here, AKT1 is linked to osteoarthritis.