MAPK8 and neurodegenerative disease: Moreover, it downregulated apoptotic (p53, caspase-3, JNK pathway) and inflammatory (NF-κB, nNOS, TNF-α) markers, demonstrating its ability to suppress OS, apoptosis and neuroinflammation in the brain, altogether preventing histopathological changes in the hippocampus and suggesting its great potential in alleviating the neurotoxic effects of chemotherapy, but also its potential in the therapy of OS-related neurodegenerative diseases [295].