TP53 and neuroblastoma: Although there is not enough evidence for a transcription-independent p53 action in neuronal cells, a p53 translocation to mitochondria has been observed in human SH-SY5Y neuroblastoma cells exposed to chlorpyrifos, an acetylcholinesterase inhibitor that induces OS, suggesting that, in some circumstances, mitochondrial p53 activity could be involved in neuronal apoptosis [127].