In accordance with this, despite the evidence of increased DNA damage in AD brains, levels of acetylated p53 and DNA damage responders transcriptionally regulated by p53 are found to be reduced, suggesting a breakdown in the p53-mediated DNA damage response pathway, probably due to p53 aggregation and cytoplasmic sequestration, or possibly interactions with tau oligomers [144]. Here, MAPT is linked to Alzheimer disease.