As the roles of the Nrf2, NF-κB and MAPK pathways in anti-oxidative and neuroinflammatory responses have been described in detail by others [54,55,64,74,75,76], we review the role of the p53 pathway in the development and progression of neurodegenerative diseases and discuss its contribution to OS- and neuroinflammatory-related events in detail. Here, NFKB1 is linked to neurodegenerative disease.