SOD1 and Parkinson disease: In a transgenic mouse model of PD with overexpression of mutant A30P human α-synuclein and haplodeficiency for superoxide dismutase (SOD) 2, a SOD isoform localized within the mitochondrial matrix, a more advanced synucleinopathy was observed, demonstrating that a reduced capacity for ROS scavenging exacerbates aggregation of α-synuclein [16].