The physiological relevance of these findings has been confirmed in the mouse brain where Aβ25-35 promoted p53 accumulation, dendrite disruption and neuronal apoptosis in the hippocampus and cortex, clearly demonstrating the important role of p53 in determining susceptibility to Aβ toxicity, and the potential of targeting p53 in AD [10,146]. Here, TP53 is linked to Alzheimer disease.