The neuroprotective effects of kaempferol were confirmed in an MPTP-induced mouse model of PD, where kaempferol improved striatal dopamine levels, increased the number of dopaminergic cells and improved behavioral deficits, likely by raising the anti-oxidative capacity, as evidenced by the restoration of SOD and GSH-Px activity, and the reduced MDA content [285]. The gene discussed is SOD1; the disease is Parkinson disease.