Therefore, we investigated the therapeutic effects of Cimicifugae Rhizoma on ovalbumin (OVA)-induced asthma and analyzed the expression of proteins including Nrf2, HO-1, NQO1, MMP-9, and NF-κB, focusing on antioxidant functions, to elucidate the mechanism of action of Cimicifugae Rhizoma in order to prove its potential as an asthma treatment. The gene discussed is NFE2L2; the disease is asthma.