In skin aging, IL-6 is a regulator correlated with the generation of wrinkles on the skin, whereas COX-2 is well known to mediate the synthesis of prostaglandin E2 (PGE2), a lipid-derived signaling molecule involved in the production of MMP-1 and the suppression of collagen biosynthesis in HDFs [30]. This evidence concerns the gene MMP1 and skin aging.