MAPK3 and cancer: Polyphenols have a molecular basis to induce cancer cell death by the down-regulation of oncogenic survival kinases such as PI3K and Akt, D-type cyclins, cyclin-dependent kinases (CDKs), cell proliferation regulators that include Erk1/2, angiogenic factors such as VEGF, FGFR1, and MIC-1 and transcription factors such as NF-kβ, NRF2, and STATs etc. [87].