Furthermore, abdominal obesity has been linked to the development of dyslipidemia, hypertension, type 2 diabetes, and CVD due to the visceral fat accumulation that negatively affects ROS levels and causes insulin resistance IR by activating NF-κB resulting in IRS-1 malfunction and degradation and impaired insulin-stimulated glucose uptake [6]. The gene discussed is IRS1; the disease is type 2 diabetes mellitus.