HIF1A and leukemia: Furthermore, our results in K562 cells showing enhanced glycolytic flux associated with GATA-1S along with a large body of literature data reporting that increased glucose metabolism is a common feature of leukemia cells [55,56,57,58], linked to constitutively activation of HIF-1α pathway [3,59,60] prompted us to examine HIF-1α mRNA levels in these AML samples.