SFRP2 and malignant colon neoplasm: In colon cancer cell lines, anthocyanin extract from BRB suppressed the activity and protein expression of DNA methyltransferase enzymes, DNMT1 and DNMT3B, and demethylated WNT upstream regulators, CDKN2A, SFRP2, SFRP5, and WIF1 [32].