TXN and Familial prostate cancer: Interestingly, Rodriguez-Garcia [9] reported that while the apoptotic effect of CUR on LNCaP and PC-3 prostate cancer cells was ROS-dependent and was associated with thioredoxin oxidation, the polyphenol silibinin, which reduced ROS levels and prevented thioredoxin oxidation in these cells, produced only a cytostatic effect.