FOS and gingivitis: The main findings were: (i) TEES-10® significantly increase PDL cell viability in LPS induced inflammatory condition; (ii) TEES-10® significantly decreased expression of inflammatory mediators such as NF-κB, p-ERK, COX-2, c-Fos and p-STAT and increased expression of anti-inflammatory mediators such as PPARγ; (iii) daily intake of TEES-10® would improve gingival health with significantly decreased number of gingivitis patients and reduced MMP-8 concentration.