PTPN5 and Alzheimer disease: In addition to the regulations studied here, including the increase in STEP61 activity, phosphatase than regulated the synaptic activity, which establishes a neuropathological mechanism not yet described for damage caused by general trauma, but if it has been previously described for other diseases such as AD, HD, and schizophrenia [17,28,49], what which reaffirms the concept that brain trauma should be treated as a chronic process rather than an acute phenomenon [2,8].