The recombinant human MG53 (rhMG53) protein has been shown to protect various cell types against membrane disruption when applied to the extracellular environment, and it ameliorates pathology associated with muscular dystrophy [29], acute lung injury [30], myocardial infarction [31], acute kidney injury [32], and ischemic brain damage [33] in animal models. Here, TRIM72 is linked to acute kidney injury.