PCSK1 and neuroblastoma: Moreover, Nec-1 attenuated the cell death induced by H2O2 in human neuroblastoma SH-SY5Y cells, and this effect was greater in undifferentiated (UN-) cells when compared to retinoic acid (RA)-differentiated ones suggesting some common mechanisms for a pro-survival effect of Nec-1 and RA [46].