PCSK1 and Alzheimer disease: Although oxidative stress and necroptosis have been evidenced to be involved in the pathogenesis of AD [114], and although there are some data (Table 1) showing neuroprotective effects of Nec-1 in cellular models of this pathology [115,116,117,118], there is a lack of studies showing a direct link between oxidative stress and necroptosis in this type of neuronal degeneration.