Regarding AD, in the model of spatial memory impairment in rats induced by neuroinflammation (LPS), Nec-1 attenuated cognitive deficits and reduced the level of necroptotic (RIP1, RIP3), apoptotic (Bax/Bcl2, caspase-8 and caspase-3) and oxidative stress (MDA) parameters and increased antioxidant defense (SOD, GSH and catalase) in the hippocampus and frontal cortex [139]. This evidence concerns the gene PCSK1 and Alzheimer disease.