Oxidative stress, which induces degeneration of dopaminergic neurons of the substantia nigra in Parkinson’s disease (PD) is accompanied by a decrease in detoxification enzymes (GSH), increase in Fe2+ and autoxidation of dopamine, enhanced metabolism of dopamine via MAO B, microglia activation, enhanced release of glutamate and NO production, disturbed Ca2+ homeostasis and defect of mitochondrial ETC complex I [15,16]. This evidence concerns the gene MAOB and Parkinson disease.