Patients with UTUC and UBUC who had high SERPINE2 expression exhibited worse OS than those with low expression (UTUC, p = 0.003; UBUC, p = 0.014; log-rank test); similar results were observed for DFS (UTUC, p = 0.031; UBUC, p = 0.033; log-rank test). The gene discussed is SERPINE2; the disease is renal pelvis/ureter urothelial carcinoma.