SOST and obesity due to melanocortin 4 receptor deficiency: Based on the peculiar postmenopausal osteoporosis risk in obesity and the involvement of the Wnt pathway in the link between osteogenesis and adipogenesis, we sought to explore the role of circulating sclerostin on skeletal bone in pre- and post-menopausal women in relation to body composition, glucose homeostasis and a comprehensive set of bone/adipose tissue markers in women with obesity.