Recently, studies suggest that PTX3, along with other biomarkers (such as Interleukin-6 (IL-6), PCT, troponin T, monocyte chemoattractant protein 1 (MCP), proadrenomedullin (proADM), or angiopoietin (Ang) 1/2)) are closely relevant to the severity of patients with sepsis and septic shock and outcome prediction of sepsis and may be a potential biomarker of disease stratification [16,17,18,19,20,21,22]. The gene discussed is IL6; the disease is Sepsis.