Most of these findings were in line with previous studies [30,31,32,33,34], for instance, higher levels of circulating PTX3 in non-survivors in patients with septic shock compared to survivors [27], and higher PTX3 were correlated with coagulation dysfunction [30], cardiovascular failure [32,34] or renal failure [33] in severe sepsis/acute coronary syndrome/chronic kidney disease. This evidence concerns the gene PTX3 and kidney failure.