PTEN and Familial adenomatous polyposis: Intestinal polyposis syndromes can be divided, based on histology, into broad categories of familial adenomatous polyposis (FAP), hamartomatous polyposis syndromes (mainly including Peutz–Jeghers Syndrome (PJS), PTEN-associated hamartomatous syndromes, Cronkhite–Canada syndrome, and familial juvenile polyposis), and other rare polyposis syndromes such as serrated polyposis syndrome and hereditary mixed polyposis syndrome.