Moreover, since deficiency in enzymes downstream of DPD, such as dihydropyrimidase (DHP) and/or β-ureidopropionase (UDP), could alter the 5,6-Dihydrouracil catabolic pathway [57], our finding supports the possibility that DPD function could indicate an error of 5,6-Dihydrouracil metabolism detected in metabolomic analysis in our female ischemic stroke patients [54]. The gene discussed is DPYD; the disease is ischemic stroke.