The lack of correlation between leptin levels and the levels of heart-failure-specific biomarkers, N-terminal pro-brain natriuretic peptide (NT-proBNP), mid-regional pro-atrial natriuretic peptide (MR-proANP) and galectin-3 was also found by Dadarlat et al. [62], who studied overweight and obese patients diagnosed with HF. This evidence concerns the gene NPPB and heart failure.