LEP and coronary artery disorder: On the other hand, there are reports that plasma leptin concentrations in CAD patients have been associated with echocardiographic parameters of ventricular remodelling (negative association with left ventricular posterior wall thickness and positive association with left ventricular relative wall thickness) [43] and impaired left ventricle diastolic (positive association with E/E’ and negative association with E/A), but not systolic, function [42,59].