HDAC1 and leukemia: Specifically, significantly enriched signatures that overlap between our studies included androgen signaling, breast cancer, and leukemia related pathways (see [20] and Supplementary Materials File S4; FDR < 0.05); Furthermore, key regulators of neoplastic processes and transcriptional dysregulation included genes such as JUN, SMAD3, MYC, HDAC1 and BRCA1 that were also part of the regulatory networks associated with rs999944.