Specifically, significantly enriched signatures that overlap between our studies included androgen signaling, breast cancer, and leukemia related pathways (see [20] and Supplementary Materials File S4; FDR < 0.05); Furthermore, key regulators of neoplastic processes and transcriptional dysregulation included genes such as JUN, SMAD3, MYC, HDAC1 and BRCA1 that were also part of the regulatory networks associated with rs999944. This evidence concerns the gene SMAD3 and breast cancer.