BCL6 is associated with biological activities of DLBCL cells by suppressing the expression of wide range of genetic factor included in numerous signaling pathways including CD40 in BCR signaling, T-cell mediated B-cells inactivation, the ability to detect as well as respond to DNA damage through repressing of the TP53 protein in TP53/ATR mediated DNA damage response, the induction of apoptosis by suppressing BCL2 in BCL2/BCL2L1 mediated apoptosis and plasma cells differentiation through PRDM1/BLIMP1 suppression [85]. Here, BCR is linked to diffuse large B-cell lymphoma.