Upon further review of the literature, we found the following cases of positive SARS-CoV-2 CSF RT–PCR: three cases of meningoencephalitis [63,64,65], two cases of seizure [66,67] and cases of headache with impaired consciousness [68]; none of these cases had IgM or IgG reports available in CSF. The gene discussed is CD40LG; the disease is meningoencephalitis.