In a model of AD, utilizing transgenic mice carrying the Swedish familial AD mutant of human amyloid precursor protein APP695, CD200 suppresses microglial inflammation, enhances microglial phagocytosis, attenuates the loss of NPC proliferation and differentiation, and promotes dendritic density, thus preventing the loss of spatial learning and memory abilities [180,181]. Here, CD200 is linked to Alzheimer disease.