However, the functional effects of TNFR-II are complex and may depend on cell type as demonstrated in a murine experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, where microglial TNFR-II was protective while its expression on infiltrating myeloid cells was pathogenic [233]. Here, TNFRSF1B is linked to experimental autoimmune encephalomyelitis.