Correspondingly, brain injury in animal models activates microglial inflammatory responses via TLR [169,170,171] while signaling from damaged neurons via HGMB1-TLR4 plays a role in neurite degeneration and cognitive impairment in 5xFAD mice that model Alzheimer’s Disease (AD) amyloid pathology [172]. The gene discussed is TLR4; the disease is Alzheimer disease.