A worldwide case-control GWAS in 673 KLS cases and ethnically matched 15,341 controls found a strong significant association within the 3′region of the Tetratricopeptide Repeat And Ankyrin Repeat Containing 1 (TRANK1) gene locus, previously associated with bipolar disorder and schizophrenia. The gene discussed is TRANK1; the disease is schizophrenia.