As an increased expression of LINC00152 has been linked to features of aggressiveness in other tumor types,19 we correlated LINC00152 expression with several molecular markers of CLL clones capable of predicting disease evolution (i.e., IGHV mutational status, CD38 expression, alterations of chromosomal asset, and modifications of TP53). The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.