SLC16A2 and hyperinsulinemic hypoglycemia, familial, 4: In 38 patients who received treatment for more than 2 years, the increase in body height-for-age Z-score from baseline to last visit compared with the natural history of treatment-naïve patients with MCT8 deficiency was more pronounced (mean increase 0.89 SD; 95% CI, 0.23-1.55; P = 0.0178, Supplementary Figure 5B and Supplementary Table 2 (12)).