This study showed that baseline stage III and IV WHO clinical stage of HIV, low baseline Body Mass Index (<18.5 kg/m2), baseline CD4 count <100cells/mm3, having history of TB co-infection, having history of lost to follow up, poor adherence to antiretroviral drugs and initiation of ART after two years of diagnosis with HIV positive were factors associated with first-line antiretroviral treatment failure. Here, CD4 is linked to coinfection.