Hypoalbuminemia, hypocholesterolemia, lymphopenia, and hypocalcemia have been associated with IL, while other possible markers such as α1-proteinase inhibitor (α1-PI), blood urea nitrogen (BUN), C-reactive protein (CRP), and packed cell volume (PCV) have also been investigated for the abovementioned purposes [2,6]; similarly, in the review by Craven et al. other molecules such as cobalamin, perinuclear antineutrophil cytoplasmic antibodies, S100A12 (calgranulin-C), and calprotectin were studied in dogs presenting protein-losing enteropathy [7]. This evidence concerns the gene S100A12 and Hypocholesterolemia.