GRB2 and neoplasm: Regarding tumor grade, the higher expression of VEGF-B (log FC = 10.8, p = 0.002), GRB2 (log FC = 2.4, p = 0.01) and RAC1 (log FC = 1.8, p = 0.02) genes were detected in mammary carcinoma tumor tissue, compared to adjacent tissue in group of all breed dogs with tumor grade III (n = 13) (Figure 2).