In this study we have chosen a panel of cancer related genes (VEGF-B, VEGF-A, FLT-1, KDR, ERBB2, EGFR, GRB2, RAC1, CDH1 and HYAL-1) in CMTs because of their importance in the signaling pathways of mammary tumors and scarcity of studies done on the molecular level. This evidence concerns the gene GRB2 and breast cancer.