GRB2 and neoplasm: Genes encoding vascular endothelial growth factors A and B (VEGF-A, VEGF-B) and their receptors 1 and 2 (FLT1, KDR), epidermal growth factor receptor (EGFR), tyrosine-protein kinase erbB-2 receptor (ERBB2/HER2), Growth Factor Receptor Bound Protein 2 (GRB2), Ras-related C3 botulinum toxin substrate 1 precursor (RAC1), are all involved in the PI3K/Akt/mTOR (phosphatidyl inositol 3 kinase/kinase B protein/rapamycin target in mammals) signaling pathway which is the hallmark of breast carcinogenesis [18].