DT388IL3 is composed of diphtheria toxin (DT388 including the translocation and catalytic domains) linked to the interleukin 3 (IL3) but 26,292 (Fv)-PE38KDEL is composed of single-chain Fvs fused to a 38 kd fragment of Pseudomonas exotoxin A. Despite the difference in the type of toxin and the binding moiety, these two targeted toxins are similar in the receptor and the targeted cancer, interleukin-3 receptor (IL-3Ralpha, CD123) and acute myeloid leukemia (AML), respectively. The gene discussed is IL3; the disease is acute myeloid leukemia.