The demonstration that CypD-/- mice are protected from high dose AA-induced acute kidney injury is consistent with studies showing that CypD-/- mice are protected from tubular epithelial cell death and loss of kidney function following cisplatin administration or renal ischaemia/reperfusion injury (IRI) [10,11,12], and that treatment with a cyclophilin inhibitor can protect against IRI-induced acute kidney injury [23]. The gene discussed is PPIF; the disease is acute kidney injury.