By contrast, another study found that CypD-/- mice exhibit worse glomerulosclerosis in a model of streptozotocin-induced type 1 diabetic kidney disease, while treatment with a cyclophilin inhibitor failed to modify the development of glomerulosclerosis in the db/db model of type 2 diabetic kidney disease [25]. This evidence concerns the gene PPIF and glomerulosclerosis.