ACTA1 and renal fibrosis: Day 28 AA CypD-/- mice were not protected from renal fibrosis, with no appreciable difference compared to day 28 AA WT mice in terms of collagen IV deposition (Figure 7D,E), increased mRNA levels for collagen I, α-SMA, CD68 or CD206 (Figure 7F–I), or the loss of CD31+ peritubular capillaries (Figure 8B,D,E).