In all evaluated prostate cancer cell lines, we found a significant increase of expression of ESR2 (* p < 0.05, ** p < 0.01) after co-exposure to 5 μM DON and 100 nM DHEA, while for the PNT1A cells the effect was opposite and the expression was significantly decreased (*** p < 0.001). Here, ESR2 is linked to Familial prostate cancer.