PAX4 and Zinc deficiency: Zinc deficiency in the embryos of zebrafish exposed to iAs did not affect mortality and development, but an adverse effect was observed with regard to the reduction of activity of the embryos and genes associated with oxidative stress and insulin production (decreased mRNA levels of 8-oxoguanine DNA glycosylase, nuclear factor (erythroid-derived 2)-like 2, and paired box 4) [65].