Although the primary tumor marker for detecting recurrence in cases undergoing total thyroidectomy and radioiodine treatment is the level of thyroid specific thyroglobulin, in patients with thyroglobulin-antibodies, the value can be over- or underestimated, which makes it difficult to detect recurrence.[11,15,16] The serum thyroglobulin level is determined by measuring the residual amount of malignant and normal thyroid tissue, degree of injury to thyroid tissue (including fine needle biopsy, operative resection, and RAI), and levels of thyroid-stimulating hormone.[17]. The gene discussed is TG; the disease is neoplasm.