BRAF and neoplasm: Larger tumor diameter, lymph node metastasis, and pathological tumor types have been reported to have a higher recurrence rate.[9] The 2015 American Thyroid Associated guideline describes several factors that affect the risk of recurrence, such as extrathyroidal extension, lymph node involvement, multifocality, and BRAF gene mutation status.[11] However, predicting disease recurrence and prognosis in patients undergoing thyroidectomy is clinically difficult.