Chien et al found that the enhancer of zeste homolog 2 could promote metastasis in triple-negative breast cancer through regulating TIMP2 and MMPs.[12] Wang et al showed that TIMP2 gene polymorphism (rs2277698) was related to breast cancer risk in a Han Chinese cohort.[15] Zhang et al discovered long noncoding RNA FENDRR could suppress the progression via regulating miR-761/TIMP2 in non-small-cell lung cancer.[16] More researches are needed to discover the molecular mechanisms of TIMP2 in various types of breast cancer. The gene discussed is EZH2; the disease is breast cancer.