TIMP2 and osteosarcoma: In osteosarcoma, miR-93 directly targeted TIMP2 which was associated with poor overall survival and prognosis.[17] In co-expression network assay, we showed TIMP2 correlated with the regulation of EMT (SNAI2 and FN1), cell adhesion (integrin family, COL1A2, COL6A3, and COL3A1), and angiogenesis (MMP2, VEGFC), which we had not investigated further and warranted further study.