Here, we found that MO infection promotes the expression of pro-inflammatory cytokines (IL-1β, IL18, and TNF-α) in MH-S cells in caspase-8, p53-, and ROS-dependent manners, suggesting that MO infection may induce apoptosis by stimulating inflammatory cytokines expression; however, the underlying molecular mechanism needs further clarifications. The gene discussed is IL18; the disease is infection.