CD28 and cancer: Consequent to our interests in using the IA1 secretome to activate resting PBMC to more efficiently kill cancer cells while preventing adverse events (e.g., cytokine storms), we more directly compared the miRNA expression profile of IA1 to pan T cell (anti-CD3/CD28; Fig. 4A), TA1 (Fig. 4B) and IA2 (Fig. 4C) activation via volcano plot analyses.