The biologic functions of CD4+CD8+ T cells remain unclear with, perhaps most, studies reporting a pro-inflammatory role in cancers though some evidence of an immunosuppressive role has been reported (Bohner et al. 2019; Overgaard et al. 2015; Parel and Chizzolini 2004; Rahemtullah et al. 2006). The gene discussed is CD4; the disease is cancer.